| Description |
Scrapie is a naturally occurring, infectious, neurodegenerative disease of sheep and goats characterised by vacuolar or spongy changes in the central nervous system (CNS). It has been recognised as a clinical disorder for more than 250 years, and is now classified as a transmissible spongiform encephalopathy (TSE), or prion disease, defined by the accumulation of an abnormal form (referred to as PrPSc) of a host membrane glycoprotein (prion protein or PrP), in the CNS. |